Job Opportunity

Associate Scientist / Sr Research Associate – Structural Biology

Location: San Diego, CA, US
Department: Drug Discovery
Employment Type: Full Time
Reference Number: 2128115

Job Description Summary

The Drug Discovery team at Mirati is responsible for the invention, optimization, and characterization of small molecules as clinical candidates for the Mirati research portfolio. Mirati is seeking a candidate with protein purification experience to join the Drug Discovery team at the Research Associate / Sr. Research Associate level within the Structural Biology group.

Your Responsibilities

The ideal candidate has a background in protein manipulation and crystallization. In addition, you are organized, collaborative, methodical and able to use your critical thinking skills to resolve technical issues.

  • Implement protein purification protocols on an AKTA for a wide range of protein targets that require multiple chromatography steps.
  • Execute a variety of protein manipulation protocols-e.g., buffer exchange, dialysis, concentration, biotinylation, protease cleavage.
  • Protein analysis using SDS-PAGE and HPLC methods.
  • Co-crystallize proteins using crystallographic robotic systems-e.g., Mosquito crystallization robot, Formulatrix robotic imagers-with general guidance.
  • Clearly document all procedures, experiments, and resulting data.
  • Contribute to protein purification reports and deliver data in a concise and timely manner.
  • Assist in maintaining the day-to-day operations in the protein chemistry lab and follow best practices for handling equipment. Ensure proteins are safely stored, equipment is operational, and the lab remains clean.
  • Communicate with and learn quickly from Structural Biology team members.
  • Maintain an evolving inventory of proteins, compounds, and chemicals.

What is Required

  • Demonstrated problem-solving skills, scientific creativity, and ability to think logically & critically.
  • Knowledge of protein chemistry protocols and subsequent analysis techniques.
  • Experience working with proteins in a research lab setting.
  • Ability to implement protocols quickly and precisely with general guidance, while developing a robust understanding and critical thinking about procedures.
  • Excellent organizational, time-management, interpersonal, and communication skills.
  • The candidate will hold a bachelor's degree in biochemistry or a related field with a minimum of 2 years' experience in a lab setting.
  • Role is on-site at company HQ in San Diego and requires COVID-19 vaccine or weekly negative COVID-19 test results.

About Mirati Therapeutics

Mirati Therapeutics is a late-stage biotechnology company whose mission is to discover, design and deliver breakthrough therapies to transform the lives of patients with cancer and their loved ones. The company is relentlessly focused on bringing forward therapies that address areas of high unmet need, including lung cancer, and advancing a pipeline of novel therapeutics targeting the genetic and immunological drivers of cancer. Mirati is using its scientific expertise to develop novel solutions in two registration-enabling programs: adagrasib (MRTX849), an investigational small molecule, potent and selective KRASG12C inhibitor, as monotherapy and in combination with other agents, and sitravatinib, an investigational spectrum-selective inhibitor of receptor tyrosine kinases in combination with checkpoint inhibitor therapies. Mirati is also advancing its differentiated preclinical portfolio, including MRTX1133, an investigational KRASG12D inhibitor, and other oncology discovery programs. Unified for patients, Mirati's vision is to unlock the science behind the promise of a life beyond cancer.

For more information about Mirati Therapeutics, visit us at or follow us on Twitter and LinkedIn. 

Why Join?

At Mirati, we have an unapologetic and relentless focus on our mission to transform the lives of patients with cancer and their loved ones. Patients and their families motivate us to work smarter, faster and better. We are driven by the knowledge that our efforts can one-day deliver life-saving therapies for the people who need us most. Urgency, open-mindedness, accountability and collaboration ground our work. These shared values are central to who we are, what we do and how we do it.

Our people fuel our success. They are fearless and passionate in their daily pursuit of our mission. We are committed to continuing to create a company and experience that attracts and keeps the best people. When you want your days to count and the work you do to matter, discovering and delivering potentially life-changing therapies is more than a job, it's the chance to be part of something bigger.

We believe diverse professional experiences and an inclusive culture can drive better outcomes for patients. We want employees to be authentic and use their perspectives to contribute to our mission in a meaningful way.

Mirati cultivates an environment where:

  • An entrepreneurial attitude is encouraged
  • Our people are empowered to speak up, embrace the gray and achieve solutions
  • Diverse experiences are an important of part making the best decisions
  • We laugh and have fun as a work family

No matter the role, we are unified by our passion for helping patients, and are inspired by a single vision - to unlock the science behind the promise of a life beyond cancer. Together, we own Mirati's success.

Learn more at

Mirati is an Equal Opportunity Employer (EOE) - we celebrate diverse experiences without regard to race, color, religion, creed, gender identity or expression, age, national origin or ancestry, citizenship, disability, sexual orientation, marital status, pregnancy, veteran status, membership in the uniformed services, genetic information, or any other basis protected by applicable law.

Notice to Third Party Agencies: Please note that Mirati Therapeutics Inc. does not accept unsolicited resumes from recruiters or employment agencies.