|Job Description||Associate Scientist|
Mirati Therapeutics is seeking a highly motivated and collaborative scientist to support oncology programs within the research department. The candidate will have hands-on expertise in mammalian cell biology and in vivo pharmacology. The candidate will primarily support drug discovery-stage research programs. Responsibilities include in vivo pharmacology, animal handling, dosing (oral, IP, etc.), cell/tumor implant, tumor measurements, PK/PD studies, compound formulation, identification and development of clinically-relevant cell line models, development of cell-based biomarker assays, genetic-based and drug mechanism of action studies. The candidate may also support translational-stage programs. Responsibilities include identifying responder populations, putative patient selection and proof of mechanism biomarkers, efficacious combinations and understanding mechanisms of intrinsic and acquired resistance.
- Independently design, execute and interpret experiments.
- Support drug discovery projects which includes developing relevant assays and generating primary data packages.
- Generate in vivo pharmacokinetic and pharmacodynamic data in relevant tumor models.
- Manage PK/PD, tumor growth inhibition and related in vivo studies across multiple projects from experimental design through execution. Includes tumor cell implant, tumor measurement and staging, dosing and tissue collection.
- Use gain-of-function (over expression) and loss-of-function (RNAi, CRISPR/Cas) approaches to study gene function in various cellular contexts.
- Validate and study targets using ChIP-PCR, qRT-PCR, Western, IP, ELISAs, etc.
- Develop and routinely run target-based and phenotypic assays in mammalian cell culture systems.
- Use a variety of molecular and cellular approaches to dissect molecular signaling pathways to elucidate gene function and drug action in vitro and in vivo.
- Identify effective combinations including combinations involving chemotherapies, targeted therapies, or immune-modulatory agents.
- Identify clinically-tractable biomarkers that may guide patient selection or early-stage drug development.
- Effectively communicate experimental plans and results. Maintain an up-to-date electronic notebook. Contribute to non-clinical pharmacology study reports and other regulatory submissions.
- Work/collaborate effectively across the research and development teams.
- BS/MS or equivalent with 0 – 3 years lab research experience in biology or related field.
- Excellent written and verbal communication skills.
- Experience with drug discovery process, pharmacology and drug development.
- Experience with in vivo models, including patient-derived xenografts, syngeneic, immunocompetent models and cell line xenografts.