We believe that our current and future success as a biopharmaceutical company depends on the contribution and dedication of each of our employees. We are proud to have built a strong team of highly-motivated and skilled people. Thank you for your interest in Mirati Therapeutics.

To apply for one of the positions listed below, please send your cv to

Senior Scientist/Principal Scientist

Location: San Diego, CA
Reports to: Chief Scientific Officer


  • Responsible for research strategy, design, and execution of research programs providing comprehensive data sets enabling advancement of oncology drug discovery and preclinical and clinical development programs.
  • Key efforts will be directed at 1) discovery, characterization and mechanistic understanding of new targeted anticancer drug candidates, 2) understanding the molecular basis of sensitivity & resistance to novel targeted agents (insight toward patient selection strategy), 3) identifying strategies to reverse resistance to intrinsic or acquired resistance to agents 4) investigating rational combination strategies and to 5) identify and develop biomarkers designed to enable demonstration of pharmacodynamic effects and/or to enable patient selection.
  • Position will be involved with the design, execution and interpretation of lab-based experiments.
  • Drive lab-based research efforts for drug discovery, preclinical development, and translational research.
  • Key member of oncology discovery and preclinical development programs with in-depth translational work to support clinical path and strategy for POC.
  • The scope of research for this position includes in vitro assay development, ex vivo assay development and analysis, molecular/cellular biology, and design and interpretation of in vivo lab model based research. This role may also potentially extend to clinical assay development, sample analysis, and interpretation.  Experience and understanding of cancer epigenetic pathways is desired.
Qualifications and Experience:
  • BS with >7 yrs or MS with > 3 yrs or PhD with postdoctoral experience in a relevant biological scientific discipline in a laboratory environment with cancer research background and understanding of cancer epigenetics preferred.
  • Relevant experience in a cancer R&D laboratory environment with biopharmaceutical/biotech experience preferred.
  • Strong understanding of key components and process of drug discovery, applied pharmacology, and drug development.
  • Strong understanding of cancer epigenetic pathways and epigenetic drug discovery techniques.
  • Growth, maintenance and expansion of mammalian tumor cell lines and development of target-based and phenotypic measurements required.
  • Prior bioassay automation experience is preferred.
  • Experience in utilizing relevant models and applied technologies and concepts including but not limited to genetic engineering, stable gene expression/knockdown platforms, cell and tumor biology, molecular profiling techniques, immunohistochemistry/immunocytochemistry, immunoprecipitation/immunoblotting, ELISA, FACS.
  • Establishment and utilization of mouse tumor models (orthotopic, GEMMs, PDX), in vivo molecular imaging, etc.

Clinical Research Scientist/Clinician

Location: San Diego
Reporting to: Executive Director, Clinical Science


  • As a Clinical Research Scientist/Clinician, this person will be responsible for the design, implementation, conduct, interpretation and reporting of clinical trials
  • The candidate will work closely with other members of the Clinical Science group, Medical Directors, members of Mirati's development and Executive Leadership teams, external vendors and contract research organizations (CROs), to establish and execute the clinical development strategy for one or more compounds from lead development in discovery to Phase I-III clinical trials
  • Develop and/or oversee the development of all documents required for the conduct of clinical trials
  • Provide direction and participate in the selection of study investigational sites and maintain relationships with investigators and key opinion leaders
  • Participate in vendor selection and oversight of full service CROs and specialty services
  • Provide oversight of study conduct and integrity, data quality, planning and execution of interim and final analyses and study reporting

Qualifications and Experience:

  • BS (Science degree) with 7+ years, MS/RN with 5+ years, MD or PhD with 3+ years of clinical development experience in industry setting, Oncology therapeutic area expertise preferred
  • Knowledge of clinical science, clinical operations and clinical project management
  • Experience with CRO oversight
  • Expected competencies:
    • Working knowledge of ICH/GCP guidelines
    • Effective written/verbal communication (e.g. able to adjust style/contents to suit the audience/purpose)
    • Ability to work independently as well as collaboratively in a multidisciplinary setting
    • Ability to work well under pressure
    • Ability to apply technical expertise and make sound decisions
    • Ability to influence without authority
    • Flexibility and willingness to adapt in a changing environment

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