Careers

We believe that our current and future success as a biopharmaceutical company depends on the contribution and dedication of each of our employees. We are proud to have built a strong team of highly-motivated and skilled people. Thank you for your interest in Mirati Therapeutics.

To apply for one of the positions listed below, please send your cv to careers@mirati.com

Senior Scientist/Principal Scientist

Location: San Diego, CA
Reports to: Chief Scientific Officer
   

Responsibilities:

  • Responsible for research strategy, design, and execution of research programs providing comprehensive data sets enabling advancement of oncology drug discovery and preclinical and clinical development programs.
  • Key efforts will be directed at 1) discovery, characterization and mechanistic understanding of new targeted anticancer drug candidates, 2) understanding the molecular basis of sensitivity & resistance to novel targeted agents (insight toward patient selection strategy), 3) identifying strategies to reverse resistance to intrinsic or acquired resistance to agents 4) investigating rational combination strategies and to 5) identify and develop biomarkers designed to enable demonstration of pharmacodynamic effects and/or to enable patient selection.
  • Position will be involved with the design, execution and interpretation of lab-based experiments.
  • Drive lab-based research efforts for drug discovery, preclinical development, and translational research.
  • Key member of oncology discovery and preclinical development programs with in-depth translational work to support clinical path and strategy for POC.
  • The scope of research for this position includes in vitro assay development, ex vivo assay development and analysis, molecular/cellular biology, and design and interpretation of in vivo lab model based research. This role may also potentially extend to clinical assay development, sample analysis, and interpretation.  Experience and understanding of cancer epigenetic pathways is desired.
Qualifications and Experience:
  • BS with >7 yrs or MS with > 3 yrs or PhD with postdoctoral experience in a relevant biological scientific discipline in a laboratory environment with cancer research background and understanding of cancer epigenetics preferred.
  • Relevant experience in a cancer R&D laboratory environment with biopharmaceutical/biotech experience preferred.
  • Strong understanding of key components and process of drug discovery, applied pharmacology, and drug development.
  • Strong understanding of cancer epigenetic pathways and epigenetic drug discovery techniques.
  • Growth, maintenance and expansion of mammalian tumor cell lines and development of target-based and phenotypic measurements required.
  • Prior bioassay automation experience is preferred.
  • Experience in utilizing relevant models and applied technologies and concepts including but not limited to genetic engineering, stable gene expression/knockdown platforms, cell and tumor biology, molecular profiling techniques, immunohistochemistry/immunocytochemistry, immunoprecipitation/immunoblotting, ELISA, FACS.
  • Establishment and utilization of mouse tumor models (orthotopic, GEMMs, PDX), in vivo molecular imaging, etc.
 

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